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FLASH GENE
Symbol ANGPTL1 contributors: npt - updated : 04-04-2006
HGNC name angiopoietin-like 1
HGNC id 489
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a 21 aa signal peptide
  • a N-terminal coiled-coil domain as well as a highly hydrophobic region
  • a C-terminal fibrinogen-like domain
  • several potential glycosylation sites
  • calcium binding motif
    • conjugated GlycoP
    isoforms Precursor a mature form of 470 aa for 54.3 kda
    HOMOLOGY
    interspecies homolog to murine Angptl1
    intraspecies homolog to ANGPT1
    homolog to ANGPT2
    homolog to ANGPTL2
    Homologene
    FAMILY
  • vascular endothelial growth factor family
  • angiopoietin family
    • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as an anti-angiogenic molecule
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS