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FLASH GENE
Symbol ANGPTL1 contributors: npt - updated : 04-04-2006
HGNC name angiopoietin-like 1
HGNC id 489
DNA
TYPE functioning gene
STRUCTURE 21.00 kb     6 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388716 1 LOC388716 COP1 1q24.2 constitutive photomorphogenic protein LOC391140 1 similar to 60S ribosomal protein L13 (A52) PLAC3 1q23-q25 placenta-specific 3 ASTN 1q25.2 astrotactin LOC57795 1q24.1-q25.3 hypothetical protein from clone 24828 RGPR 1q24.2-q25.2 hypothetical protein from clone 24828 LOC391141 1 similar to Quinone oxidoreductase (NADPH:quinone reductase) (Zeta-crystallin) RASAL2 1q25 RAS protein activator like 2 DKFZP564J047 1q24.3 hypothetical protein DKFZp564J047 FLJ10244 1q24.3 Ral-A exchange factor RalGPS2 ANGPTL1 1q24.2 angiopoietin-like 1 FAM20B 1q25 family with sequence similarity 20, member B TOR3A 1q24.2-q24.3 torsin family 3, member A ABL2 1q24-q25 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) SOAT1 1q25 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 FLJ32940 1q24.3 hypothetical protein FLJ32940 NPHS2 1q25-q31 nephrosis 2, idiopathic, steroid-resistant (podocin) LOC126860 1q24.3 similar to centaurin, gamma 2 TDRD5 1q24.2 tudor domain containing 5 MGC16664 1q25.1 hypothetical protein MGC16664 LOC163590 1q25.1 AF464140 IFRG15 1q25.1 IFRG15 protein LAP1B 1q24.2 lamina-associated polypeptide 1B CAP350 1p36.13-q41 lamina-associated polypeptide 1B QSCN6 1q24 quiescin Q6 FLJ23867 1q25.1 hypothetical protein FLJ23867 LHX4 1q24.1-q24.3 LIM homeobox 4 LOC388717 1 LOC388717 ACBD6 1q25.1 acyl-Coenzyme A binding domain containing 6 XPR1 1q25 xenotropic and polytropic retrovirus receptor KIAA1614 1q25.1 KIAA1614 protein LOC391142 1 hypothetical gene supported by AJ249778; NM_001531 STX6 1p36 syntaxin 6 MR1 1q25.3 major histocompatibility complex, class I-related IER5 1q25.1 immediate early response 5 LOC284646 1q25.1 hypothetical gene supported by BC039493 CACNA1E 1q25-q31 calcium channel, voltage-dependent, alpha 1E subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3555 56.7 491 - Kim
- - 4000 - - - Kim
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
 vessel   highly
Digestiveintestinesmall intestine  highly
 pancreas exocrine   moderately
Endocrineadrenal gland   moderately
 parathyroid   highly
 thyroid   highly
Lymphoid/Immunelymph node   predominantly
Nervousnerve   moderately
Reproductivefemale systemuterus  highly
 male systemtestis  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Epithelialbarrier/liningendothelium  
Epithelialsecretoryglandularendocrine 
Muscularstriatumcardiac  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text placenta highly, umbilical cord moderately
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a 21 aa signal peptide
  • a N-terminal coiled-coil domain as well as a highly hydrophobic region
  • a C-terminal fibrinogen-like domain
  • several potential glycosylation sites
  • calcium binding motif
  • conjugated GlycoP
    isoforms Precursor a mature form of 470 aa for 54.3 kda
    HOMOLOGY
    interspecies homolog to murine Angptl1
    intraspecies homolog to ANGPT1
    homolog to ANGPT2
    homolog to ANGPTL2
    Homologene
    FAMILY
  • vascular endothelial growth factor family
  • angiopoietin family
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as an anti-angiogenic molecule
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS