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FLASH GENE

Symbol

ANGPTL1

contributors: npt - updated : 04-04-2006

HGNC name	angiopoietin-like 1
HGNC id	489

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	21.00 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 3555 56.7 491 - Kim variant 2 - - 4000 - - - Kim

EXPRESSION

Type

widely

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately   vessel       highly Digestive intestine small intestine     highly   pancreas exocrine       moderately Endocrine adrenal gland       moderately   parathyroid       highly   thyroid       highly Lymphoid/Immune lymph node       predominantly Nervous nerve       moderately Reproductive female system uterus     highly   male system testis     moderately Respiratory respiratory tract larynx     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Epithelial barrier/lining endothelium     Epithelial secretory glandular endocrine   Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal, pregnancy

Text	placenta highly, umbilical cord moderately

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a 21 aa signal peptide
	a N-terminal coiled-coil domain as well as a highly hydrophobic region
	a C-terminal fibrinogen-like domain
	several potential glycosylation sites
	calcium binding motif

conjugated

GlycoP

isoforms

Precursor

a mature form of 470 aa for 54.3 kda

HOMOLOGY

interspecies

homolog to murine Angptl1

intraspecies	homolog to ANGPT1
	homolog to ANGPT2
	homolog to ANGPTL2

Homologene

FAMILY	vascular endothelial growth factor family
	angiopoietin family

CATEGORY

regulatory , signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

acting as an anti-angiogenic molecule

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS