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FLASH GENE
Symbol DHX58 contributors: mct/npt - updated : 22-06-2016
HGNC name DEXH (Asp-Glu-X-His) box polypeptide 58
HGNC id 29517
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two conserved domains DEAD/H (Asp-Glu-Ala-Asp/His)
  • a zinc-binding domain structurally related to GDP/GTP exchange factors of Rab-like GTPases (Cui 2008)
  • a helicase C terminal domain, responsible for RNA binding (Li 2009), and regulatory domain modulating DDX58-dependent signaling via competition for dsRNA, another pattern sensed by DDX58, while a fully functional DHX58 is required to augment IFIH1-dependent signaling (Pipig 2009)
    • HOMOLOGY
    interspecies homolog to murine Lgp2
    intraspecies homolog to DDX58, IFIH1
    Homologene
    FAMILY
  • helicase family
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • functioning as a negative regulator of host defense (Saito 2007)
  • cytosolic pattern recognition receptor detecting single-stranded or double-stranded RNA in virally infected cells (Li 2009)
  • differentially regulates DHX58- and IFIH1-dependent RNA sensing in an unknown manner (Pippig 2009)
  • regulates the signaling of the DDX58-like receptors
  • required for signaling, and plays an important role in modulating signaling by IFIH1 and DDX58, presumably through heterocomplex formation and/or by serving as a sink for RNAs (Murali 2008)
  • has striking structural similarity to the helicase domain of the superfamily 2 DNA helicase, HEF (Murali 2008)
  • RD modulates RIG-I-dependent signaling via competition for dsRNA, another pattern sensed by RIG-I, while a fully functional LGP2 is required to augment MDA5-dependent signaling
  • facilitates viral RNA recognition by DDX58 and IFIH1 through its ATPase domain (Satoh 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PUM1, PUM2 increased double-stranded (ds) RNA binding affinity of DHX58, and likely facilitates viral RNA recognition by DHX58 through its chaperon-like function
  • MAVS plays a key role in the signal transduction of DHX58-mediated antiviral response
  • ZYX serves as a scaffold for the interactions between DHX58 and MAVS
  • BST2 is a negative regulator of DHX58-mediated type I IFN signaling by targeting MAVS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS