Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

DHX58

contributors: mct/npt - updated : 22-06-2016

HGNC name	DEXH (Asp-Glu-X-His) box polypeptide 58
HGNC id	29517

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	11.33 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024119 14 - 2631 NP_077024 76 678 - Li (2009)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system breast

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular

cell lineage
cell lines	neoplastic mammary cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two conserved domains DEAD/H (Asp-Glu-Ala-Asp/His)
	a zinc-binding domain structurally related to GDP/GTP exchange factors of Rab-like GTPases (Cui 2008)
	a helicase C terminal domain, responsible for RNA binding (Li 2009), and regulatory domain modulating DDX58-dependent signaling via competition for dsRNA, another pattern sensed by DDX58, while a fully functional DHX58 is required to augment IFIH1-dependent signaling (Pipig 2009)

HOMOLOGY

interspecies

homolog to murine Lgp2

intraspecies

homolog to DDX58, IFIH1

Homologene

FAMILY

helicase family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	functioning as a negative regulator of host defense (Saito 2007)
	cytosolic pattern recognition receptor detecting single-stranded or double-stranded RNA in virally infected cells (Li 2009)
	differentially regulates DHX58- and IFIH1-dependent RNA sensing in an unknown manner (Pippig 2009)
	regulates the signaling of the DDX58-like receptors
	required for signaling, and plays an important role in modulating signaling by IFIH1 and DDX58, presumably through heterocomplex formation and/or by serving as a sink for RNAs (Murali 2008)
	has striking structural similarity to the helicase domain of the superfamily 2 DNA helicase, HEF (Murali 2008)
	RD modulates RIG-I-dependent signaling via competition for dsRNA, another pattern sensed by RIG-I, while a fully functional LGP2 is required to augment MDA5-dependent signaling
	facilitates viral RNA recognition by DDX58 and IFIH1 through its ATPase domain (Satoh 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PUM1, PUM2 increased double-stranded (ds) RNA binding affinity of DHX58, and likely facilitates viral RNA recognition by DHX58 through its chaperon-like function
	MAVS plays a key role in the signal transduction of DHX58-mediated antiviral response
	ZYX serves as a scaffold for the interactions between DHX58 and MAVS
	BST2 is a negative regulator of DHX58-mediated type I IFN signaling by targeting MAVS

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS