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FLASH GENE
Symbol FABP7 contributors: mct - updated : 17-02-2017
HGNC name fatty acid binding protein 7, brain
HGNC id 3562
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • repeated structure, topology beta barrel and remarkable structural signature
    • HOMOLOGY
    interspecies homolog to murine Fabp7
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be playing roles in fatty acid uptake, transport, and metabolism
  • involved in cell proliferation and invasion and may be associated with tumor progression in melanoma
  • may have a role in pulmonary development and in the pathogenesis of congenital cystic adenomatoid malformation
  • may function as a tumor progression gene
  • role in differentiation and/or proliferation of glial cells through regulation of lipid metabolism and/or signaling
  • is likely involved in the proliferation of astrocytes by controlling cellular fatty acid homeostasis
  • FABP7 and FABP5 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation
  • FABP7 controls lipid raft function through the regulation of CAV1 expression and is involved in the response of astrocytes to the external stimuli
  • astrocytic FABP7 is important for dendritic arbor growth, neuronal excitatory synapse formation, and synaptic transmission
  • might play an important role in maintaining retinal vasculature
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FABP7 is a direct target of repression by NR1D1
  • lack of NR1D1 increased ARNTL, NPAS2, CLOCK, and FABP7 expression, confirming the direct regulation of these genes by NR1D1 also in the brain
    • cell & other
    REGULATION
    activated by PAX6 (FABP7 promoter activity is upregulated by PAX6)
    induced by NOTCH1 and RELN
    Other regulated by PKC and the MAPK/ERK1/2 pathway through independent mechanisms in melanoma cell lines
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in fetal CCAM (congenital cystic adenomatoid malformation) compared with fetal lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can be used as a potential diagnostic biomarker of early-stage melanoma systemic spreading in blood
    • Therapy target
    ANIMAL & CELL MODELS
  • Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes show fragmented sleep
  • Fabp7-/- mice have significantly decreased retinal venular caliber retinal arteriolar fractal dimension compared with WT littermates