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FLASH GENE

Symbol

RAB6C

contributors: mct/npt - updated : 16-06-2009

HGNC name	RAB6C, member RAS oncogene family
HGNC id	16525

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	RAS-GTPase superfamily
	Rab family
	RAB6 subfamily

CATEGORY

protooncogene , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
text	mainly located in the cytosol and capable of binding to GTP (Tian 2005)

basic FUNCTION	involved in drug resistance in multi drug resistant breast cancer cell line
	protein transport
	regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum
	playing a negative role gene in multidrug resistance development through its proapoptotic potential that is regulated by multiple mechanisms at the transcription level, and one of these mechanisms is linked to the TP53 gene (Tian 2007)
	negative regulator during multidrug resistance (MDR) development (Tian 2005)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

drug

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi (Wanschers 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in multidrug resistance (MDR) cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs (Tian 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS