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FLASH GENE
Symbol RAB6C contributors: mct/npt - updated : 16-06-2009
HGNC name RAB6C, member RAS oncogene family
HGNC id 16525
DNA
TYPE functioning gene
STRUCTURE 3.08 kb     1 Exon(s)
regulatory sequence Promoter (TATA box)
Binding site
text structure
  • a Tp53-binding site in its promoter ( RAB6Ccould be regulated by the TP53 gene) (Tian 2007)
  • a CpG (CpG 23) that was close to the TATA-like box was constantly methylated in the promoter of drug-resistant breast cancer epithelial (Tian 2005)
  • promoter function was significantly attenuated in multidrug resistance (MFC7/AdrR) relative to non-MDR (MCF7/WT) cells (Tian 2005)
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3077 28.2 254 - Tian (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
    Reproductivefemale systemovary   
     female systembreastmammary gland  
    Visualeyeanterior segmentiris  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines HCF/Ad2R cell line
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • RAS-GTPase superfamily
  • Rab family
  • RAB6 subfamily
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text mainly located in the cytosol and capable of binding to GTP (Tian 2005)
    basic FUNCTION
  • involved in drug resistance in multi drug resistant breast cancer cell line
  • protein transport
  • regulator of membrane traffic from the golgi apparatus towards the endoplasmic reticulum
  • playing a negative role gene in multidrug resistance development through its proapoptotic potential that is regulated by multiple mechanisms at the transcription level, and one of these mechanisms is linked to the TP53 gene (Tian 2007)
  • negative regulator during multidrug resistance (MDR) development (Tian 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi (Wanschers 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in multidrug resistance (MDR) cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs (Tian 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS