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FLASH GENE
Symbol GABARAPL1 contributors: mct/np - updated : 30-08-2015
HGNC name GABA(A) receptor-associated protein like 1
HGNC id 4068
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • N terminal tubulin binding motif
  • HOMOLOGY
    interspecies ortholog to murine Gabarapl1
    ortholog to murine Gabarapl2
    intraspecies homolog to GABARAP
    homolog to GABARAPL2
    homolog to GABARAPL3
    Homologene
    FAMILY
  • microtubule-associated protein (MAP) family, GABARAP subfamaily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons
  • promoting tubulin assembly and microtubule bundling
  • new member of the GABARAP family involved in the transport of GABA(A) receptor
  • could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons
  • with its widespread distribution in the nervous system and its predominantly hydrophobic interactions, may have chaperone-like effects for many cell surface proteins along the biosynthesis pathway
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • displays a complex regulation that is different from that of other GABARAP family members
  • tumor repressor inhibiting WNT signaling via mediating DVL2 degradation through the autophagy pathway
  • important role of ATG8 homologues may be to act as a scaffold for the assembly of autophagy complexes
  • macroautophagic sequestration did not require the MAP1LC3 subfamily, but, intriguingly, GABARAP, GABARAPL1, GABARAPL2 are essential
  • GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are not essential for autophagosome formation but are critical for autophagosome-lysosome fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with tubulin and GABA(A) receptor
  • ATG4B displays increased activity against GABARAPL1
  • interacting with STBD1, and AIM in STBD1 is responsible for its interaction with GABARAPL1
  • HSP90AA1 interacts and protects GABARAPL1 from its degradation by the proteasome
  • strong evidence that transcriptional repression plays a major role in regulating GARAPL1/MAP1LC3A levels, and this up-regulation results in an increase in the size of the autophagosome
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • ULK1 interacted most strongly with GABARAP and GABARAPL1, but it also interacted with GABARAPL2, MAP1LC3A, and MAP1LC3C (pMID: 23043107)
  • GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy
  • FKBP8 is an GABARAPL1, GABARAPL2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS