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FLASH GENE
Symbol GABARAPL1 contributors: mct/np - updated : 30-08-2015
HGNC name GABA(A) receptor-associated protein like 1
HGNC id 4068
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Nervousbrain   predominantly Homo sapiens
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral  predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • N terminal tubulin binding motif
  • HOMOLOGY
    interspecies ortholog to murine Gabarapl1
    ortholog to murine Gabarapl2
    intraspecies homolog to GABARAP
    homolog to GABARAPL2
    homolog to GABARAPL3
    Homologene
    FAMILY
  • microtubule-associated protein (MAP) family, GABARAP subfamaily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons
  • promoting tubulin assembly and microtubule bundling
  • new member of the GABARAP family involved in the transport of GABA(A) receptor
  • could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons
  • with its widespread distribution in the nervous system and its predominantly hydrophobic interactions, may have chaperone-like effects for many cell surface proteins along the biosynthesis pathway
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • displays a complex regulation that is different from that of other GABARAP family members
  • tumor repressor inhibiting WNT signaling via mediating DVL2 degradation through the autophagy pathway
  • important role of ATG8 homologues may be to act as a scaffold for the assembly of autophagy complexes
  • macroautophagic sequestration did not require the MAP1LC3 subfamily, but, intriguingly, GABARAP, GABARAPL1, GABARAPL2 are essential
  • GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are not essential for autophagosome formation but are critical for autophagosome-lysosome fusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with tubulin and GABA(A) receptor
  • ATG4B displays increased activity against GABARAPL1
  • interacting with STBD1, and AIM in STBD1 is responsible for its interaction with GABARAPL1
  • HSP90AA1 interacts and protects GABARAPL1 from its degradation by the proteasome
  • strong evidence that transcriptional repression plays a major role in regulating GARAPL1/MAP1LC3A levels, and this up-regulation results in an increase in the size of the autophagosome
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • ULK1 interacted most strongly with GABARAP and GABARAPL1, but it also interacted with GABARAPL2, MAP1LC3A, and MAP1LC3C (pMID: 23043107)
  • GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy
  • FKBP8 is an GABARAPL1, GABARAPL2-interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS