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FLASH GENE
Symbol RNF17 contributors: mct - updated : 11-03-2014
HGNC name ring finger protein 17
HGNC id 10060
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TUDOR domain
  • a RING finger motif
    • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Rnf17
    Homologene
    FAMILY
  • RING finger protein family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may have transcriptional activator activity
  • RING finger protein that interacts with mad members of the Myc oncoprotein network
  • enhances MYC function and regulates some target genes in common with glucocorticoid hormones
  • may play a role in the assembly of RNF17 granules
  • component of a novel germ cell nuage and is required for differentiation of male germ cells
  • with TDRD1, and TDRD6, play evolutionarily conserved roles in germinal granule/nuage formation and germ cell specification and differentiation
  • RNF17/TDRD4 are required for spermiogenesis
  • TDRD5, TDRD7, RNF17 proteins play distinct roles during male germ cell development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text premeiotic stages of spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of a novel nuage in male germ cells--the RNF17 granule, prominent in late pachytene and diplotene spermatocytes, and in elongating spermatids
    • INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rnf17-deficient male mice were sterile and exhibited a complete arrest in round spermatids