Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF17 contributors: mct - updated : 11-03-2014
HGNC name ring finger protein 17
HGNC id 10060
DNA
TYPE functioning gene
STRUCTURE 115.76 kb     36 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
36 - 5120 184.6 1623 - 2000 10961928
RNF17IL
36 - 5126 184.2 1619 - 2000 10961928
RNF17IS
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductivespermatogonia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TUDOR domain
  • a RING finger motif
    • conjugated MetalloP
    HOMOLOGY
    interspecies ortholog to murine Rnf17
    Homologene
    FAMILY
  • RING finger protein family
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may have transcriptional activator activity
  • RING finger protein that interacts with mad members of the Myc oncoprotein network
  • enhances MYC function and regulates some target genes in common with glucocorticoid hormones
  • may play a role in the assembly of RNF17 granules
  • component of a novel germ cell nuage and is required for differentiation of male germ cells
  • with TDRD1, and TDRD6, play evolutionarily conserved roles in germinal granule/nuage formation and germ cell specification and differentiation
  • RNF17/TDRD4 are required for spermiogenesis
  • TDRD5, TDRD7, RNF17 proteins play distinct roles during male germ cell development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text premeiotic stages of spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • component of a novel nuage in male germ cells--the RNF17 granule, prominent in late pachytene and diplotene spermatocytes, and in elongating spermatids
    • INTERACTION
    DNA binding
    RNA binding
    small molecule metal binding,
  • Zn2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rnf17-deficient male mice were sterile and exhibited a complete arrest in round spermatids