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FLASH GENE
Symbol KDM2A contributors: mct - updated : 01-06-2017
HGNC name lysine (K)-specific demethylase 2A
HGNC id 13606
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 40 AA F-box motif
  • a JmjC-domain, a novel demethylase signature motif
  • a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (CBX5) interaction motif that mediates direct binding between KDM2A and CBX5
  • three leucine-rich repeats
  • six highly degenerated leucine-rich (LRR) repeats at the C terminus
    • HOMOLOGY
    Homologene
    FAMILY
  • F-box protein family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,centromere
    text associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere
    basic FUNCTION
  • phosphorylation dependent ubiquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • demethylates H3-methyl-K36 and generates formaldehyde and succinate
  • required to maintain the heterochromatic state, and playing a role in epigenetic silencing
  • required to sustain centromeric integrity and genomic stability, particularly during mitosis
  • histone H3K36 demethylase, and a negative regulator of NFkappaB
  • its expression is driven by NF-kappaB, revealing a negative regulatory feedback loop
  • regulator of rRNA transcription in response to starvation
  • H3K36 demethylase that also contains a CXXC domain, and enriched in the CGI fraction
  • its demethylase activity is known to reduce expression of genes and eventually inhibit proliferation of cells
  • KDM2A transcriptionally represses the HDAC3 gene by removing methyl groups from dimethylated H3K36 at the HDAC3 promoter in KDM2A-overexpressing non-small cell lung cancer (NSCLC) cells
  • is a histone demethylase that selectively removes mono- and di-methylation from histone H3K36
  • plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival
  • likely a direct role for KDM2A in chromatin silencing
    • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component one of the four subunits of the E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1, Fbox protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • EREG, was a downstream target of KDM2A, and EREG mediated KDM2A regulation of MSC differentiation
  • is a H3K4 demethylase that regulates cell proliferation through CDKN2B and CDKN1B in stem cells from apical papilla (SCAPs)
  • likely a regulatory role for KDM2A in breast cancer cell invasion and migration, through the regulation of E2F1 function
  • silencing KDM2A, a histone demethylase and BCL6 co-repressor, derepressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter
    • cell & other
    REGULATION
    Other activity is stimulated by starvation to reduce ribosomal RNA transcription
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    greatly decreased NFkappaB activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS