Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KDM2A

contributors: mct - updated : 01-06-2017

HGNC name	lysine (K)-specific demethylase 2A
HGNC id	13606

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       lowly Nervous brain hindbrain cerebellum       brain basal nuclei       Reproductive female system ovary         male system testis       Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

cell cycle

cell cycle, checkpoint, G1S

Text	neural tube

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	40 AA F-box motif
	a JmjC-domain, a novel demethylase signature motif
	a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finger, a PHD domain and a newly identified Heterochromatin Protein 1 (CBX5) interaction motif that mediates direct binding between KDM2A and CBX5
	three leucine-rich repeats
	six highly degenerated leucine-rich (LRR) repeats at the C terminus

HOMOLOGY

Homologene

FAMILY

F-box protein family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome,centromere
text	associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere

basic FUNCTION	phosphorylation dependent ubiquination
	substrate recognition subunit of SCF ubiquitin protein ligase complex
	demethylates H3-methyl-K36 and generates formaldehyde and succinate
	required to maintain the heterochromatic state, and playing a role in epigenetic silencing
	required to sustain centromeric integrity and genomic stability, particularly during mitosis
	histone H3K36 demethylase, and a negative regulator of NFkappaB
	its expression is driven by NF-kappaB, revealing a negative regulatory feedback loop
	regulator of rRNA transcription in response to starvation
	H3K36 demethylase that also contains a CXXC domain, and enriched in the CGI fraction
	its demethylase activity is known to reduce expression of genes and eventually inhibit proliferation of cells
	KDM2A transcriptionally represses the HDAC3 gene by removing methyl groups from dimethylated H3K36 at the HDAC3 promoter in KDM2A-overexpressing non-small cell lung cancer (NSCLC) cells
	is a histone demethylase that selectively removes mono- and di-methylation from histone H3K36
	plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival
	likely a direct role for KDM2A in chromatin silencing

CELLULAR PROCESS

protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

one of the four subunits of the E3 ubiquitin protein ligase complex (SCF) with SKP1, CUL1, RBX1, Fbox protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box

INTERACTION

DNA

RNA

small molecule

protein	various target proteins
	EREG, was a downstream target of KDM2A, and EREG mediated KDM2A regulation of MSC differentiation
	is a H3K4 demethylase that regulates cell proliferation through CDKN2B and CDKN1B in stem cells from apical papilla (SCAPs)
	likely a regulatory role for KDM2A in breast cancer cell invasion and migration, through the regulation of E2F1 function
	silencing KDM2A, a histone demethylase and BCL6 co-repressor, derepressed SFRP2 transcription by increasing histone H3K4 and H3K36 methylation at the SFRP2 promoter

cell & other

REGULATION

Other

activity is stimulated by starvation to reduce ribosomal RNA transcription

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   greatly decreased NFkappaB activity

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS