Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DCLRE1A contributors: mct/ - updated : 07-11-2015
HGNC name DNA cross-link repair 1A
HGNC id 17660
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domain constituting a metal dependent hydrolase
  • a metallo-beta-lactamase and beta-CASP domains
  • a functional PIP box (PCNA-interacting protein box)
  • a UBZ (ubiquitin binding zinc finger), required for assembly of DLCRE1A into nuclear focus
    • HOMOLOGY
    interspecies homolog to murine SNM1
    homolog to yeast Pso2
    Homologene
    FAMILY
  • DNA repair metallo-beta-lactamase (DRMBL) family
  • beta-CASP family
  • SNM1 family of nucleases
  • extended family of eukaryotic nuclease containing a motif related to the prokaryotic metallo-beta-lactamase (MBL) fold
    • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • putative hydrolase, involved in V(D)J recombination/DNA repair
  • functioning in DNA repair, V(D)J recombination and RNA processing
  • represent a second pathway for genome stability, distinct from the Fanconi anemia pathway
  • having exonuclease activity which requires the conserved beta-lactamase domain
  • functioning in an early mitotic stress checkpoint that is distinct from the well-characterized spindle checkpoint that regulates the metaphase-to-anaphase transition
  • acting with ATM to promote the G1 cell cycle checkpoint
  • have the surprising function of being involved in an early mitotic or prophase checkpoint in response to spindle stress, a role that does not appear to involve a DNA damage response
  • DLCRE1A and DLCRE1B participate in etoposide-induced apoptosis
  • DLCRE1A and DLCRE1B act before mitochondria and caspase activation during apoptosis
  • DCLRE1A and DCLRE1B might exhibit some redundancy in interstrand cross-link repair
  • DCLRE1A has greater affinity for single-stranded DNA over double-stranded DNA that is not observed with DCLRE1B
  • is a key exonuclease during replication-dependent and transcription-coupled interstrand crosslink repair
  • remarkable ability of DCLRE1A to accommodate and efficiently digest highly distorted DNA substrates, such as those containing DNA lesions
    • CELLULAR PROCESS nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text double strand break repair and V(D)J recombination
    PATHWAY
    metabolism
    signaling
    RAD18-PCNA-DLCRE1A activation pathway appears to be independent of another DNA crosslink repair pathway, the FA (Fanconi anemia) pathway
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with PIAS1 in nuclear focus formation (interaction required for interstrand cross-link (ICL) repair)
  • collaboration between DCLRE1A and ERCC4-ERCC1 is necessary to initiate ICL repair in replicating human cells
  • ERCC6 coordinates the resolution of interstrand crosslink , possibly in a transcription-associated repair mechanism involving DCLRE1A, and defects in the process could contribute to the post-mitotic degenerative pathologies associated with Cockayne syndrome
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS