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FLASH GENE
Symbol DCLRE1A contributors: mct/ - updated : 07-11-2015
HGNC name DNA cross-link repair 1A
HGNC id 17660
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineparathyroid   highly
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domain constituting a metal dependent hydrolase
  • a metallo-beta-lactamase and beta-CASP domains
  • a functional PIP box (PCNA-interacting protein box)
  • a UBZ (ubiquitin binding zinc finger), required for assembly of DLCRE1A into nuclear focus
    • HOMOLOGY
    interspecies homolog to murine SNM1
    homolog to yeast Pso2
    Homologene
    FAMILY
  • DNA repair metallo-beta-lactamase (DRMBL) family
  • beta-CASP family
  • SNM1 family of nucleases
  • extended family of eukaryotic nuclease containing a motif related to the prokaryotic metallo-beta-lactamase (MBL) fold
    • CATEGORY enzyme , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • putative hydrolase, involved in V(D)J recombination/DNA repair
  • functioning in DNA repair, V(D)J recombination and RNA processing
  • represent a second pathway for genome stability, distinct from the Fanconi anemia pathway
  • having exonuclease activity which requires the conserved beta-lactamase domain
  • functioning in an early mitotic stress checkpoint that is distinct from the well-characterized spindle checkpoint that regulates the metaphase-to-anaphase transition
  • acting with ATM to promote the G1 cell cycle checkpoint
  • have the surprising function of being involved in an early mitotic or prophase checkpoint in response to spindle stress, a role that does not appear to involve a DNA damage response
  • DLCRE1A and DLCRE1B participate in etoposide-induced apoptosis
  • DLCRE1A and DLCRE1B act before mitochondria and caspase activation during apoptosis
  • DCLRE1A and DCLRE1B might exhibit some redundancy in interstrand cross-link repair
  • DCLRE1A has greater affinity for single-stranded DNA over double-stranded DNA that is not observed with DCLRE1B
  • is a key exonuclease during replication-dependent and transcription-coupled interstrand crosslink repair
  • remarkable ability of DCLRE1A to accommodate and efficiently digest highly distorted DNA substrates, such as those containing DNA lesions
    • CELLULAR PROCESS nucleotide, recombination
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    text double strand break repair and V(D)J recombination
    PATHWAY
    metabolism
    signaling
    RAD18-PCNA-DLCRE1A activation pathway appears to be independent of another DNA crosslink repair pathway, the FA (Fanconi anemia) pathway
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • interacts with PIAS1 in nuclear focus formation (interaction required for interstrand cross-link (ICL) repair)
  • collaboration between DCLRE1A and ERCC4-ERCC1 is necessary to initiate ICL repair in replicating human cells
  • ERCC6 coordinates the resolution of interstrand crosslink , possibly in a transcription-associated repair mechanism involving DCLRE1A, and defects in the process could contribute to the post-mitotic degenerative pathologies associated with Cockayne syndrome
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS