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FLASH GENE
Symbol ADAM28 contributors: mct/pgu - updated : 06-11-2010
HGNC name ADAM metallopeptidase domain 28
HGNC id 206
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a disrupted Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
    • conjugated GlycoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text overexpressed in normal memory B cells
    basic FUNCTION
  • putatively involved in sperm maturation
  • may be playing a role in the interaction of lymphocytes with ITGA4B1-expressing leukocytes
  • playing a role in cell proliferation and progression of the lung carcinomas
  • may function as positive regulator of growth and differentiation of dental papilla mesenchymal cells and act as an important molecule mediating reciprocal epithelial-mesenchymal signaling during tooth organ development
  • involved in cell proliferation through enhanced bioavailability of IGFI released from the IGF1/IGFBP3 complex by selective IGFBP3 cleavage in breast carcinomas
  • degrading proteoglycans and may be involved in cartilage degradation in osteoarthritis
  • may promote angiogenesis in the breast carcinoma tissues by releasing vascular endothelial growth factor165 (VEGF165) after digestion of CTGF in the CTGF/VEGF165 complex
    • CELLULAR PROCESS cell life, differentiation
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • ligand for ITGA4B1
  • interact with integrins and is involved in the digestion of IGFBP3 through release of IGF1, a potent inducer of cell proliferation
  • interacting with SELPLG (ADAM28 promotes SELPLG/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with SELPLG on leukocytes under inflammatory conditions)
  • also involved in activation of EGFR, MAPK1, MAPK3 and release of CD44
  • CTGF is a novel substrate of ADAM28
    • cell & other
    REGULATION
    activated by activated by MMP-7
    induced by all-trans retinoic acid in primary chondrocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    and activated in non-small cell lung carcinomas
    tumoral     --over  
    in an activated form in human breast carcinoma cells
    tumoral     --over  
    in asbestos-related lung cancer-adenocarcinoma
    tumoral     --over  
    predominantly by carcinoma cells in the invasive breast carcinomas and is involved in carcinoma cell proliferation probably through enhanced bioavailability of insulin-like growth factor-I
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS