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FLASH GENE

Symbol

ADAM28

contributors: mct/pgu - updated : 06-11-2010

HGNC name	ADAM metallopeptidase domain 28
HGNC id	206

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with ADAMDEC1 and ADAM7
STRUCTURE	61.15 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014265 23 - 3220 NP_055080 87 775 . transmembrane form . in spleen, lymph node, and, to a lesser extent, in peripheral blood leukocytes 2010 20544843 ADAM28m typical ADAM domain structure, including signal peptide, propeptide, metalloprotease, disintegrin, cysteine-rich, EGF, and transmembrane domains 6 potential N-linked glycosylation sites NM_021777 14 splicing 2108 NP_068547 - 540 . secreted form . primarily expressed in spleen 2010 20544843 ADAM28s having signal peptide, propeptide, metalloprotease, and disintegrin domains identical to those of MDCLM 3 potential N-linked glycosylation sites

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon       stomach       highly Lymphoid/Immune lymph node       highly Reproductive male system testis     highly Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma     highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell Homo sapiens

cell lineage
cell lines	transformed B and T lymphocytes cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	domains similar to hemorrhagic snake venom proteins (HSVP)
	a disrupted Zn-binding site metalloproteinase
	a disintegrin-like domain
	a cysteine-rich domain
	an EGF-like repeat
	a transmembrane domain and a cytoplasmic tail

conjugated

GlycoP , MetalloP

HOMOLOGY

Homologene

FAMILY

ADAM (a disintegrin and metalloprotease domain) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	overexpressed in normal memory B cells

basic FUNCTION	putatively involved in sperm maturation
	may be playing a role in the interaction of lymphocytes with ITGA4B1-expressing leukocytes
	playing a role in cell proliferation and progression of the lung carcinomas
	may function as positive regulator of growth and differentiation of dental papilla mesenchymal cells and act as an important molecule mediating reciprocal epithelial-mesenchymal signaling during tooth organ development
	involved in cell proliferation through enhanced bioavailability of IGFI released from the IGF1/IGFBP3 complex by selective IGFBP3 cleavage in breast carcinomas
	degrading proteoglycans and may be involved in cartilage degradation in osteoarthritis
	may promote angiogenesis in the breast carcinoma tissues by releasing vascular endothelial growth factor165 (VEGF165) after digestion of CTGF in the CTGF/VEGF165 complex

CELLULAR PROCESS	cell life, differentiation
	protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	ligand for ITGA4B1
	interact with integrins and is involved in the digestion of IGFBP3 through release of IGF1, a potent inducer of cell proliferation
	interacting with SELPLG (ADAM28 promotes SELPLG/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with SELPLG on leukocytes under inflammatory conditions)
	also involved in activation of EGFR, MAPK1, MAPK3 and release of CD44
	CTGF is a novel substrate of ADAM28

cell & other

REGULATION

activated by

activated by MMP-7

induced by

all-trans retinoic acid in primary chondrocytes

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   and activated in non-small cell lung carcinomas tumoral     --over   in an activated form in human breast carcinoma cells tumoral     --over   in asbestos-related lung cancer-adenocarcinoma tumoral     --over   predominantly by carcinoma cells in the invasive breast carcinomas and is involved in carcinoma cell proliferation probably through enhanced bioavailability of insulin-like growth factor-I

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS