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FLASH GENE
Symbol TBCA contributors: mct/npt - updated : 14-10-2009
HGNC name tubulin folding cofactor A
HGNC id 11579
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Tbca
Homologene
FAMILY
  • TBCA family
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • capturing and stabilizing beta tubulin intermediates in a quasi-native conformation
  • playing an essential role for cell viability (Nolasco 2005)
    • CELLULAR PROCESS protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the complex of cofactors A to E leading to correctly folded beta tubulins
  • TBCE, TBCB and alpha-tubulin form a ternary complex after heterodimer dissociation, whereas the free beta-tubulin subunit is recovered by TBCA (Kortazar 2007)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS