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FLASH GENE

Symbol

TBCA

contributors: mct/npt - updated : 14-10-2009

HGNC name	tubulin folding cofactor A
HGNC id	11579

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q13.3      Physical location : 76.986.994 - 77.072.185
Synonym name	tubulin-specific chaperone A
	TCP1-chaperonin cofactor A
Synonym symbol(s)	CFA

DNA

TYPE	functioning gene
STRUCTURE	85.20 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004607 4 - 679 NP_004598 12.8 108 - Nolasco (2005)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage
cell lines	alveolar rhabdomyosarcoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Tbca

Homologene

FAMILY

TBCA family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	capturing and stabilizing beta tubulin intermediates in a quasi-native conformation
	playing an essential role for cell viability (Nolasco 2005)

CELLULAR PROCESS

protein, post translation, folding

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the complex of cofactors A to E leading to correctly folded beta tubulins
	TBCE, TBCB and alpha-tubulin form a ternary complex after heterodimer dissociation, whereas the free beta-tubulin subunit is recovered by TBCA (Kortazar 2007)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS