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FLASH GENE
Symbol TDG contributors: mct/npt - updated : 20-06-2017
HGNC name thymine-DNA glycosylase
HGNC id 11700
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • interacting domain mapped to AAs 67-110, and Val74 plays an important role in the TDG-HUS1 interaction
    • HOMOLOGY
    Homologene
    FAMILY
  • TDG/MUG DNA glycosylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine
  • key DNA glycosylase in the base excision repair (BER) pathway that repairs deaminated cytosines and 5-methyl-cytosines (Guan 2007)
  • playing a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine
  • DNA repair enzyme specific for G/T mismatches, plays a role in the regulation of gene expression through its physical interaction with transcription factors (Kim 2008)
  • dual role for TDG in promoting proper epigenetic states during development
  • is involved in the repair of G:T and G:U mismatches caused by hydrolytic deamination of 5-methylcytosine and cytosine, respectively
  • TDG regulates TGFB1-dependent promoter demethylation and expression of the CDKN2B tumor suppressor gene
  • essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation and transcription regulation (pMID: 23952905)
  • enzyme that initiates the repair of G/T and G/U mismatches, has been lately found crucial in embryonic development to maintain epigenetic stability and facilitate the active DNA demethylation
  • plays critical roles in DNA base excision repair and DNA demethylation
  • when TDG concentrations approach those of histones, TDG acts as a competitive inhibitor of EP300 histone acetylation
  • is a base excision repair (BER) enzyme, which is implicated in correction of deamination-induced DNA mismatches, the DNA demethylation process and regulation of gene expression
  • presence of BER-dependent and BER-independent functions of TDG, which are involved in regulation of cellular DNA damage responses and gene expression patterns
    • CELLULAR PROCESS nucleotide, repair, base excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting functionally with XPC in G/T mismatch repair
  • interacting with HUS1
  • associates with members of the TP53 tumor suppressor family and directly modulates their activity
  • TDG-NCOA3 interaction is important for broad range activation of steroid hormone nuclear receptors, and may also contribute significantly to further understanding of TDG-related nuclear receptor regulation
  • role of TDG in mammalian 5-methylcytosine demethylation
  • SIRT1 enhances TDG glycosylase activity and deacetylates acetylated TDG
  • TDG, as a new coactivator, promotes CTNNB1/TCFs transactivation and functionally cooperates with CREBBP in canonical WNT signaling
  • HRAS downregulated thymine-DNA glycosylase (TDG), a DNA demethylation enzyme, by inhibiting the interaction of transcription activator ING4 with TDG promoter
  • NEIL1 and NEIL2 DNA glycosylases coordinate abasic-site processing during TET-TDG DNA demethylation, and NEIL1 and NEIL2 cooperate with TDG during base excision
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels