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FLASH GENE

Symbol

TDG

contributors: mct/npt - updated : 20-06-2017

HGNC name	thymine-DNA glycosylase
HGNC id	11700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Lymphoid/Immune thymus         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

interacting domain mapped to AAs 67-110, and Val74 plays an important role in the TDG-HUS1 interaction

HOMOLOGY

Homologene

FAMILY

TDG/MUG DNA glycosylase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,PML
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine
	key DNA glycosylase in the base excision repair (BER) pathway that repairs deaminated cytosines and 5-methyl-cytosines (Guan 2007)
	playing a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine
	DNA repair enzyme specific for G/T mismatches, plays a role in the regulation of gene expression through its physical interaction with transcription factors (Kim 2008)
	dual role for TDG in promoting proper epigenetic states during development
	is involved in the repair of G:T and G:U mismatches caused by hydrolytic deamination of 5-methylcytosine and cytosine, respectively
	TDG regulates TGFB1-dependent promoter demethylation and expression of the CDKN2B tumor suppressor gene
	essential multifunctional enzyme involved in DNA base excision repair, DNA demethylation and transcription regulation (pMID: 23952905)
	enzyme that initiates the repair of G/T and G/U mismatches, has been lately found crucial in embryonic development to maintain epigenetic stability and facilitate the active DNA demethylation
	plays critical roles in DNA base excision repair and DNA demethylation
	when TDG concentrations approach those of histones, TDG acts as a competitive inhibitor of EP300 histone acetylation
	is a base excision repair (BER) enzyme, which is implicated in correction of deamination-induced DNA mismatches, the DNA demethylation process and regulation of gene expression
	presence of BER-dependent and BER-independent functions of TDG, which are involved in regulation of cellular DNA damage responses and gene expression patterns

CELLULAR PROCESS

nucleotide, repair, base excision repair

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting functionally with XPC in G/T mismatch repair
	interacting with HUS1
	associates with members of the TP53 tumor suppressor family and directly modulates their activity
	TDG-NCOA3 interaction is important for broad range activation of steroid hormone nuclear receptors, and may also contribute significantly to further understanding of TDG-related nuclear receptor regulation
	role of TDG in mammalian 5-methylcytosine demethylation
	SIRT1 enhances TDG glycosylase activity and deacetylates acetylated TDG
	TDG, as a new coactivator, promotes CTNNB1/TCFs transactivation and functionally cooperates with CREBBP in canonical WNT signaling
	HRAS downregulated thymine-DNA glycosylase (TDG), a DNA demethylation enzyme, by inhibiting the interaction of transcription activator ING4 with TDG promoter
	NEIL1 and NEIL2 DNA glycosylases coordinate abasic-site processing during TET-TDG DNA demethylation, and NEIL1 and NEIL2 cooperate with TDG during base excision

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels