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FLASH GENE

Symbol

THRA

contributors: mct - updated : 03-06-2020

HGNC name	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
HGNC id	11796

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal modulator domain,
	a central bipartite (class II) zinc finger DNA binding domain
	a C terminal ligand domain

HOMOLOGY

Homologene

FAMILY	steroid/thyroid hormone receptor superfamily
	nuclear hormone receptor family

CATEGORY

transcription factor , signaling hormone , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,chromatin/chromosome
text	shuttles rapidly between the nucleus and cytoplasm (

basic FUNCTION	nuclear hormone receptor for triiodothyronine mediating the biological activities of thyroid hormone
	exhibits a dual role as an activator or repressor of its target genes in response to thyroid hormone (T(3)(
	apparently plays an essential role in restoring the expression of the TH-regulated genes potentially involved in striatal synaptic plasticity (
	has the capacity to play an important role in virtually all developing and adult neurons
	is required for normal neural progenitor cell proliferation in human cerebral cortical development

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

thyroid

a component

INTERACTION

DNA

RNA

small molecule

protein	directly interacts with calreticulin (THRA can follows a cooperative export pathway in which both calreticulin and CRM1 play a role in facilitating efficient translocation of THRA from the nucleus to cytoplasm) (
	thyroid hormone (TH), a regulator of hepatic gluconeogenesis acts through its nuclear receptor (THRA, THRB) to induce the expression of PCK1 and G6PC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulated in breast cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurosensorial visual   inhibition of THRA, THRB locally in the retina is a therapeutic strategy for retinal degeneration

ANIMAL & CELL MODELS

thyroid receptor knock-out mouse models displaying severe neurological dysfunction