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FLASH GENE
Symbol OMG contributors: mct - updated : 09-03-2011
HGNC name oligodendrocyte myelin glycoprotein
HGNC id 8135
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight leucine-rich repeats
  • five Ser/Thr-rich repeats
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Omg
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to the interactive process required for myelination in central nervous system
  • inhibiting neurite outgrowth and axonal regeneration after brain injury
  • implicated in growth cone collapse and neurite outgrowth inhibition by signaling through the RTN4R and paired Ig-like receptor B (LILRB3)
  • physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to RTN4R
  • NOGO receptor ligand
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS