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FLASH GENE
Symbol OMG contributors: mct - updated : 09-03-2011
HGNC name oligodendrocyte myelin glycoprotein
HGNC id 8135
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralwhite matter  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Nervousoligodendrocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight leucine-rich repeats
  • five Ser/Thr-rich repeats
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Omg
    Homologene
    FAMILY
    CATEGORY adhesion , structural protein , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to the interactive process required for myelination in central nervous system
  • inhibiting neurite outgrowth and axonal regeneration after brain injury
  • implicated in growth cone collapse and neurite outgrowth inhibition by signaling through the RTN4R and paired Ig-like receptor B (LILRB3)
  • physiological roles of RTN4, MAG, OMG in processes, such as development, neuronal homeostasis, plasticity, and neurodegeneration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to RTN4R
  • NOGO receptor ligand
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS