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FLASH GENE
Symbol POLR2E contributors: mct - updated : 27-10-2011
HGNC name polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
HGNC id 9192
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY RPB5 RNA polymerase subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding C19orf2
  • hepatitis B virus X protein (HBx), a protein known to be a causative agent in the formation of hepatocellular carcinoma interacts directly with POLR2E
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS