Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol POLR2E contributors: mct - updated : 27-10-2011
HGNC name polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
HGNC id 9192
Location 19p13.3      Physical location : 1.086.579 - 1.095.391
Synonym name DNA directed RNA polymerase II polypeptide E
Synonym symbol(s) RPABC1, RPB5, XAP4, hRPB25, hsRPB5
EC.number 2.7.7.6
DNA
TYPE functioning gene
STRUCTURE 8.81 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2866 - 210 - 2011 21310960
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Skin/Tegumentskin   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY RPB5 RNA polymerase subunit family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • catalyzing the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding C19orf2
  • hepatitis B virus X protein (HBx), a protein known to be a causative agent in the formation of hepatocellular carcinoma interacts directly with POLR2E
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS