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FLASH GENE
Symbol RUNDC3A contributors: mct - updated : 28-01-2013
HGNC name RUN domain containing 3A
HGNC id 16984
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • N-terminal region contains the RUN domain, interacting with RAP2A
  • seven heptad repeats characteristic of coiled-coil domains and three potential phophorylation sites
  • a C terminal FYVE domain
    • HOMOLOGY
    interspecies homolog to murine Rundc3a (96 pc)
    Homologene
    FAMILY
  • RUNDC3A family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • acting as an effector of RAP2 in neurons
  • playing a role of small GTPases regulator
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    small GTPase mediated signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the GTP-bound form of RAP2A, specific effector of RAP2A GTPase
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    deleted with GRN in frontotemporal dementia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS