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FLASH GENE

Symbol

RUNDC3A

contributors: mct - updated : 28-01-2013

HGNC name	RUN domain containing 3A
HGNC id	16984

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     predominantly Nervous brain       highly   nerve       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	N-terminal region contains the RUN domain, interacting with RAP2A
	seven heptad repeats characteristic of coiled-coil domains and three potential phophorylation sites
	a C terminal FYVE domain

HOMOLOGY

interspecies

homolog to murine Rundc3a (96 pc)

Homologene

FAMILY

RUNDC3A family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	acting as an effector of RAP2 in neurons
	playing a role of small GTPases regulator

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

small GTPase mediated signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

interacting with the GTP-bound form of RAP2A, specific effector of RAP2A GTPase

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     deleted with GRN in frontotemporal dementia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS