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FLASH GENE
Symbol SLC2A3 contributors: np/mct - updated : 19-05-2015
HGNC name solute carrier family 2 (facilitated glucose transporter), member 3
HGNC id 11007
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative transmembrane segments (12TM)
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loop, respectively between TM2 and 3 and TM8 and 9, both with the conserved RXGRR motif
    • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 2
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • facilitated glucose transporter, probably a neuronal glucose transporter
  • has a predominant role during cardiac development
  • is the main glucose transporter responsible for transplacental transport of maternal glucose, thereby controlling the rate at which glucose is delivered to the fetus
  • is essential for the development of early post-implanted embryos
  • is of greater importance for glucose uptake early in gestation
  • hypoxia-induced increases in glucose uptake through SLC2A3 are important for lipid synthesis in macrophages, and may contribute to foam cell formation in hypoxic regions of atherosclerotic lesions
  • neuronal glucose transporter, contributing to glucose uptake and proliferation of lung tumor cells that have undergone an EMT
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of the glucose-3-transporter (SLC2A3) and the cell-adhesion protein PODXL
  • KDM3A is recruited to the SLC2A3 locus in an HIF1-dependent manner and demethylates H3K9me2 so as to upregulate its expression
  • overactivation of CAPN1 caused by calcium overload proteolyses CREB1, resulting in a reduction of SLC2A3 expression and consequently impairing glucose uptake and metabolism in AD brain
  • is a transcriptional target of ZEB1
  • ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM
  • MTOR, was involved in the regulation of SLC2A3 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    SLC2A3 duplication might serve as a genetic modifier of CHDs and/or aortic arch anomalies in individuals with del22q11
    constitutional     --over  
    in human pregnancies complicated by late-onset intrauterine growth restriction
    constitutional     --low  
    in Alzheimer Disease brain and correlates with tau pathology
    Susceptibility to myelomeningocele
    Variant & Polymorphism SNP involving the SLC2A3 gene may be associated with increased susceptibility to myelomeningocele
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential target for therapy against cancers caused by the aberrantly activated MTOR signaling
    ANIMAL & CELL MODELS
  • homozygous null deletion of Slc2a3 is embryonic lethal in mice and the heterozygous deletion is not lethal but results in intrauterine growth retardation