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FLASH GENE
Symbol SLC2A3 contributors: np/mct - updated : 19-05-2015
HGNC name solute carrier family 2 (facilitated glucose transporter), member 3
HGNC id 11007
Location 12p13.31      Physical location : 8.071.824 - 8.088.892
Synonym name glucose transporter type 3, brain
Synonym symbol(s) GLUT3, GLUTL, FLJ90380
DNA
TYPE functioning gene
STRUCTURE 17.07 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure
  • promoter contains three potential cAMP response element (CRE)-like elements, CRE1, CRE2 and CRE3
  • MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3938 - 496 - 2013 23341039
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiensFetal
    Digestiveliver     Homo sapiens
    Nervousbrain   predominantly Homo sapiens
    Reproductivefemale systemplacenta    Homo sapiens
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac   Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyocyte Homo sapiens
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments (12TM)
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loop, respectively between TM2 and 3 and TM8 and 9, both with the conserved RXGRR motif
  • HOMOLOGY
    Homologene
    FAMILY
  • solute carrier family 2
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • facilitated glucose transporter, probably a neuronal glucose transporter
  • has a predominant role during cardiac development
  • is the main glucose transporter responsible for transplacental transport of maternal glucose, thereby controlling the rate at which glucose is delivered to the fetus
  • is essential for the development of early post-implanted embryos
  • is of greater importance for glucose uptake early in gestation
  • hypoxia-induced increases in glucose uptake through SLC2A3 are important for lipid synthesis in macrophages, and may contribute to foam cell formation in hypoxic regions of atherosclerotic lesions
  • neuronal glucose transporter, contributing to glucose uptake and proliferation of lung tumor cells that have undergone an EMT
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction of the glucose-3-transporter (SLC2A3) and the cell-adhesion protein PODXL
  • KDM3A is recruited to the SLC2A3 locus in an HIF1-dependent manner and demethylates H3K9me2 so as to upregulate its expression
  • overactivation of CAPN1 caused by calcium overload proteolyses CREB1, resulting in a reduction of SLC2A3 expression and consequently impairing glucose uptake and metabolism in AD brain
  • is a transcriptional target of ZEB1
  • ZBTB7A directly binds to the promoter and represses the transcription of critical glycolytic genes, including SLC2A3, PFKP, and PKM
  • MTOR, was involved in the regulation of SLC2A3 expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   amplification    
    SLC2A3 duplication might serve as a genetic modifier of CHDs and/or aortic arch anomalies in individuals with del22q11
    constitutional     --over  
    in human pregnancies complicated by late-onset intrauterine growth restriction
    constitutional     --low  
    in Alzheimer Disease brain and correlates with tau pathology
    Susceptibility to myelomeningocele
    Variant & Polymorphism SNP involving the SLC2A3 gene may be associated with increased susceptibility to myelomeningocele
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential target for therapy against cancers caused by the aberrantly activated MTOR signaling
    ANIMAL & CELL MODELS
  • homozygous null deletion of Slc2a3 is embryonic lethal in mice and the heterozygous deletion is not lethal but results in intrauterine growth retardation