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FLASH GENE
Symbol NCKIPSD contributors: mct/npt/pgu - updated : 12-06-2010
HGNC name NCK interacting protein with SH3 domain
HGNC id 15486
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a N terminal SH3 domain
  • a proline-rich domain
  • a bipartite nuclear localization signal (NLS)
  • a serine-threonine rich region
  • C terminal hydrophobic region
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    intracellular,nucleus
    basic FUNCTION
  • playing a role in maintenance of sarcomere structure and/or in the assembly of myofibrils into sarcomere
  • involvement in the regulation of actin cytoskeleton and actin comet tail formation
  • participate in modulation of actin cytoskeleton by binding to a variety of scaffold and signaling molecules
  • key regulator of actin cytoskeletal organization
  • plays a key role in the formation of the membrane protrusions associated with cell motility
  • F-actin binding protein thought to play important roles in regulating cytoskeletal dynamics
  • plays critical roles in controlling growth cone dynamics and neurite outgrowth
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    signal transduction in the nucleus
    a component
  • formation of a NCKIPSD-BAIAP2 complex mediated through direct association of the proline-rich domain (PRD) of NCKIPSD with the SH3 domain of BAIAP2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding FHOD1
  • binding of the C terminus of SPIN90 with both the Arp2/3 complex (actin-related proteins Arp 2 and Arp 3) and G-actin activates the former, leading to actin polymerization
  • BAIAP2 is a binding partner of NCKIPSD
  • interacting with PALLD (interacts with its SH3 domains and SRC and is required for SRC-induced cytoskeletal remodeling)
  • WASL-interacting protein that binds and activates WASL to recruit the Arp2/3 complex in a Cdc42-independent manner
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    with MLL in t(3;11)(p21;q23) in therapy-related leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS