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FLASH GENE

Symbol

NCKIPSD

contributors: mct/npt/pgu - updated : 12-06-2010

HGNC name	NCK interacting protein with SH3 domain
HGNC id	15486

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Nervous brain limbic system hippocampus   highly Homo sapiens Adult

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	ubiquitous
	expressed during the early stages of neuronal development

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	a N terminal SH3 domain
	a proline-rich domain
	a bipartite nuclear localization signal (NLS)
	a serine-threonine rich region
	C terminal hydrophobic region

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor , protooncogene , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
	intracellular,nucleus

basic FUNCTION	playing a role in maintenance of sarcomere structure and/or in the assembly of myofibrils into sarcomere
	involvement in the regulation of actin cytoskeleton and actin comet tail formation
	participate in modulation of actin cytoskeleton by binding to a variety of scaffold and signaling molecules
	key regulator of actin cytoskeletal organization
	plays a key role in the formation of the membrane protrusions associated with cell motility
	F-actin binding protein thought to play important roles in regulating cytoskeletal dynamics
	plays critical roles in controlling growth cone dynamics and neurite outgrowth

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

signal transduction in the nucleus

a component

formation of a NCKIPSD-BAIAP2 complex mediated through direct association of the proline-rich domain (PRD) of NCKIPSD with the SH3 domain of BAIAP2

INTERACTION

DNA

RNA

small molecule

protein	binding FHOD1
	binding of the C terminus of SPIN90 with both the Arp2/3 complex (actin-related proteins Arp 2 and Arp 3) and G-actin activates the former, leading to actin polymerization
	BAIAP2 is a binding partner of NCKIPSD
	interacting with PALLD (interacts with its SH3 domains and SRC and is required for SRC-induced cytoskeletal remodeling)
	WASL-interacting protein that binds and activates WASL to recruit the Arp2/3 complex in a Cdc42-independent manner

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     with MLL in t(3;11)(p21;q23) in therapy-related leukemia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS