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FLASH GENE
Symbol UGT1A10 contributors: mct/npt - updated : 31-05-2010
HGNC name UDP glycosyltransferase 1 family, polypeptide A10
HGNC id 12531
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to UGT1A9 (93 p100)
Homologene
FAMILY
  • UDP-glycosyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the transfer of glucuronic acid (or other nucleotide sugars) to bilirubin
  • catalyze the glucuronidation of xenobiotics, mutagens, and reactive metabolites and thus act as indirect antioxidants (Kalthoff 2010)
  • exhibiting glucuronidating activity against metabolites of the tobacco smoke carcinogen, benzo(a)pyrene
  • having a major role in the elimination of lipophilic chemicals by glucuronidation
  • having a potential role in hepatic detoxification (Li 2007)
  • catalyzed dopamine glucuronidation at substantial rates, yielding both dopamine-4-O-glucuronide and dopamine-3-O-glucuronide (Itäaho 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by estrogen (induction of UGT1A10 mRNA expression by E(2) might be mediated through ER, and this isoform is a novel, estrogen-regulated target gene in MCF-7) (Starlard-Davenport 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS