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FLASH GENE
Symbol UGT1A10 contributors: mct/npt - updated : 31-05-2010
HGNC name UDP glycosyltransferase 1 family, polypeptide A10
HGNC id 12531
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
 liver   moderately
Urinarybladder   highly
 kidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to UGT1A9 (93 p100)
Homologene
FAMILY
  • UDP-glycosyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the transfer of glucuronic acid (or other nucleotide sugars) to bilirubin
  • catalyze the glucuronidation of xenobiotics, mutagens, and reactive metabolites and thus act as indirect antioxidants (Kalthoff 2010)
  • exhibiting glucuronidating activity against metabolites of the tobacco smoke carcinogen, benzo(a)pyrene
  • having a major role in the elimination of lipophilic chemicals by glucuronidation
  • having a potential role in hepatic detoxification (Li 2007)
  • catalyzed dopamine glucuronidation at substantial rates, yielding both dopamine-4-O-glucuronide and dopamine-3-O-glucuronide (Itäaho 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by estrogen (induction of UGT1A10 mRNA expression by E(2) might be mediated through ER, and this isoform is a novel, estrogen-regulated target gene in MCF-7) (Starlard-Davenport 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS