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FLASH GENE

Symbol

SAP30

contributors: mct - updated : 27-08-2012

HGNC name	sin3-associated polypeptide, 30kDa
HGNC id	10532

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SAP30 Sin3 interaction domain (SID) binding to PAH3 domain of SIN3A via a tripartite structural motif

HOMOLOGY

interspecies

homolog to yeast SAP30

Homologene

FAMILY

histone deacetylase complex family

CATEGORY

regulatory , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome
	intracellular,nucleus,nucleolus

basic FUNCTION	being active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones
	involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes
	SAP30L and SAP30 play active roles in recruitment of deacetylating enzymes to nucleosomes, and mediate key protein-protein and protein-DNA interactions involved in chromatin remodeling and transcription
	to play a role in complex assembly because the protein has been proposed to interact with the ING1b/ING2

CELLULAR PROCESS

nucleotide, chromatin organization, remodeling

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

histone deacetylase complex including SIN3, SAP18, HDAC1, HDAC2, RBBP4, RBBP7 and others

INTERACTION

DNA

RNA

small molecule

protein	NCOR1, NCOR2
	interacting with SAP30L (are able to target Sin3A to the nucleolus)
	associates with YY1 and it is able to enhance YY1-mediated repression in a dose-dependent manner
	in the nucleus, SAMSN1 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1
	RBP1 binds to the pocket region of RB1 via an LXCXE motif and to the SAP30 subunit of the mSin3·HDAC complex
	SAP30 interacting with SIN3A and forming a SIN3A PAH3-SAP30 SID complex that can bind to nucleic acids

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     in basal cell carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS