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FLASH GENE
Symbol SAP30 contributors: mct - updated : 27-08-2012
HGNC name sin3-associated polypeptide, 30kDa
HGNC id 10532
Location 4q34.1      Physical location : 174.292.092 - 174.298.682
Synonym name
  • Sin3 corepressor complex subunit SAP30
  • histone deacetylase complex subunit SAP30
    • DNA
    TYPE functioning gene
    STRUCTURE 6.59 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1126 - 220 - 2007 17672918
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   moderately
    Reproductivefemale systemuteruscervix moderately
    Respiratorylung   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SAP30 Sin3 interaction domain (SID) binding to PAH3 domain of SIN3A via a tripartite structural motif
    • HOMOLOGY
    interspecies homolog to yeast SAP30
    Homologene
    FAMILY histone deacetylase complex family
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • being active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones
  • involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes
  • SAP30L and SAP30 play active roles in recruitment of deacetylating enzymes to nucleosomes, and mediate key protein-protein and protein-DNA interactions involved in chromatin remodeling and transcription
  • to play a role in complex assembly because the protein has been proposed to interact with the ING1b/ING2
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • histone deacetylase complex including SIN3, SAP18, HDAC1, HDAC2, RBBP4, RBBP7 and others
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCOR1, NCOR2
  • interacting with SAP30L (are able to target Sin3A to the nucleolus)
  • associates with YY1 and it is able to enhance YY1-mediated repression in a dose-dependent manner
  • in the nucleus, SAMSN1 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1
  • RBP1 binds to the pocket region of RB1 via an LXCXE motif and to the SAP30 subunit of the mSin3·HDAC complex
  • SAP30 interacting with SIN3A and forming a SIN3A PAH3-SAP30 SID complex that can bind to nucleic acids
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in basal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS