| basic FUNCTION
| eukaryotic transcriptional regulator, mediating the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription |
|
greatly facilitated COP9 signalosome-mediated deneddylation of CUL1 |
|
playing a critical role in regulating various ubiquitin E3 ligases and their targeted cellular and developmental pathways |
|
involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment  |
|
maintains the cellular balance of cullin-RING ubiquitin ligases complexes by preventing rare F box proteins from being outcompeted for binding to CUL1 by more ample adapters |
|
functioning as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion |
|
function as a positive regulator of Cullin ligases |
|
likely to regulate cullin RING ligase activity via alternative mechanisms |
|
inhibits cullin RING ubiquitin ligases by binding unneddylated cullins |
