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FLASH GENE
Symbol CAND1 contributors: mct - updated : 27-05-2011
HGNC name cullin-associated and neddylation-dissociated 1
HGNC id 30688
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 5956 - 1230 - 2008 18826954
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Nervousbrain   moderately
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus blocks the cullin neddylation site
  • whereas the C-terminus inhibits cullin adaptor interaction
  • HOMOLOGY
    Homologene
    FAMILY cullin family
    CATEGORY unknown/unspecified , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text predominantly cytoplasmically localized
    basic FUNCTION
  • eukaryotic transcriptional regulator, mediating the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription
  • greatly facilitated COP9 signalosome-mediated deneddylation of CUL1
  • playing a critical role in regulating various ubiquitin E3 ligases and their targeted cellular and developmental pathways
  • involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment
  • maintains the cellular balance of cullin-RING ubiquitin ligases complexes by preventing rare F box proteins from being outcompeted for binding to CUL1 by more ample adapters
  • functioning as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion
  • function as a positive regulator of Cullin ligases
  • likely to regulate cullin RING ligase activity via alternative mechanisms
  • inhibits cullin RING ubiquitin ligases by binding unneddylated cullins
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the SCF(SKP1-CUL1-f-box protein) E3 ubiquitin ligase complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically binds to unmodified CUL1 but not to neddylated one
  • interaction with cullin family proteins
  • binds CUL2, CUL3, CUL4A, CUL4B and CUL5
  • binds to the components of the neddylation pathway (Cullin-RBX1, UBE2M, and DCUN1D1)(Kim 2008)
  • binds to cullins that are not conjugated with Nedd8 and not associated with substrate receptors
  • COMMD1 regulates CRL (Cullin RING ligases) activation by antagonizing CAND1 binding, and can actively displace CAND1 from CRLs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS