basic FUNCTION
| eukaryotic transcriptional regulator, mediating the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription |
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greatly facilitated COP9 signalosome-mediated deneddylation of CUL1 |
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playing a critical role in regulating various ubiquitin E3 ligases and their targeted cellular and developmental pathways |
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involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment |
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maintains the cellular balance of cullin-RING ubiquitin ligases complexes by preventing rare F box proteins from being outcompeted for binding to CUL1 by more ample adapters |
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functioning as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion |
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function as a positive regulator of Cullin ligases |
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likely to regulate cullin RING ligase activity via alternative mechanisms |
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inhibits cullin RING ubiquitin ligases by binding unneddylated cullins |