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FLASH GENE

Symbol

PSMD2

contributors: mct - updated : 12-01-2017

HGNC name	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
HGNC id	9559

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven PC repeats

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm

basic FUNCTION

acting as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins

CELLULAR PROCESS

protein

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

important fonctional component of the proteosome and in the degradation

INTERACTION

DNA

RNA

small molecule

protein

RPGRIP1L controls likely ciliary signaling by regulating the activity of the ciliary proteasome via PSMD2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	novel prognostic markers in acute myeloid leukemia with favorable outcome are PSMD2, PPARD
Therapy target
	System Type Disorder Pubmed cancer lung   potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas

ANIMAL & CELL MODELS