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FLASH GENE
Symbol PSMD2 contributors: mct - updated : 12-01-2017
HGNC name proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
HGNC id 9559
DNA
TYPE functioning gene
STRUCTURE 9.97 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status tentative : very preliminary evidence
Map cen - D13S459 - ACTN2 - RYR2 - D13S2785 - PM - D13S304 - pter
Authors Gene Map (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3076 - 908 - 1996 8774743
19 - 2655 - 778 - 1996 8774743
19 - 2644 - 744 - 1996 8774743
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven PC repeats
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • acting as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component important fonctional component of the proteosome and in the degradation
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RPGRIP1L controls likely ciliary signaling by regulating the activity of the ciliary proteasome via PSMD2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel prognostic markers in acute myeloid leukemia with favorable outcome are PSMD2, PPARD
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas
    ANIMAL & CELL MODELS