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FLASH GENE
Symbol DMAP1 contributors: mct - updated : 18-05-2011
HGNC name DNA methyltransferase 1 associated protein 1
HGNC id 18291
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative nuclear localizatio
  • a predicted coiled coil domain that may interact with stathmin
  • a Myb-like DNA binding domain
  • a SB(steadiness box) domain
  • a UEV (ubiquitin e2 variant) domain required for the interaction of the complex with ubiquitin
    • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY ubiquitin-conjugating enzyme family, UEV subfamily
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the repression or activation of transcription
  • regulator of vesicular trafficking process
  • required for the sorting of endocytic (EGF receptors) cargos
  • co-repressor that inhibits TFIIH-mediated transcriptional activity via interaction with MNAT1
  • may be involved in cell growth and differentiation
  • plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity
  • required for inhibition of CAK kinase-mediated CDK1 phosphorylation
  • has additional roles in genomic stability
  • involved in the regulation of cell cycle progression as an intrinsic negative regulator of CAK that regulates mitotic cell cycle progression
  • cell cycle regulation properties of DMAP1 are strictly related to its expression level, and DMAP1 protein has a dose-dependent anti-proliferative effect on somatic cells
    • CELLULAR PROCESS nucleotide, chromatin organization, methylation
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • component of the NuA4 histone acetyltransferase complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HDAC2-DNMT1
  • corepressor TSG101
  • facilitating the nuclear localization of C19orf2 and its corepressor activity in a dose-dependent manner by interacting with the CC domain of C19orf2
  • interacts with GGA1 and GGA3
  • interacts with PDCD6IP/AIP1
  • activates DNMT1 preferentially at sites of homologous recombination repair
  • intrinsic negative cell cycle regulator that modulates the CAK kinase activity via interaction with MNAT1 (the coiled-coil domain in the middle of MNAT1 interacts with the C-terminal half of DMAP1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS