basic FUNCTION
| involved in the repression or activation of transcription |
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regulator of vesicular trafficking process |
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required for the sorting of endocytic (EGF receptors) cargos |
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co-repressor that inhibits TFIIH-mediated transcriptional activity via interaction with MNAT1 |
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may be involved in cell growth and differentiation |
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plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity |
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required for inhibition of CAK kinase-mediated CDK1 phosphorylation |
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has additional roles in genomic stability |
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involved in the regulation of cell cycle progression as an intrinsic negative regulator of CAK that regulates mitotic cell cycle progression |
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cell cycle regulation properties of DMAP1 are strictly related to its expression level, and DMAP1 protein has a dose-dependent anti-proliferative effect on somatic cells |