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FLASH GENE
Symbol PCDHA5 contributors: npt - updated : 19-11-2009
HGNC name protocadherin alpha 5
HGNC id 8671
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text developing brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • six extracellular cadherin repeats
  • a transmembrane segment encoded by a unique exon
  • a cytoplasmic tail identical for each protein in the cluster
  • two PXXP motifs and a putative SH3 protein-binding site
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Pcdha5 protocadherin alpha 5
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily
  • protocadherin family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral membrane protein type 1, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text playing a putative role in cell-cell interaction critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • cytoplasmic domain putatively connecting to intermediate filaments
    • cell & other
  • cells expressing the same protocadherin
    • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS