Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PCDHA5

contributors: npt - updated : 19-11-2009

HGNC name	protocadherin alpha 5
HGNC id	8671

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem, component of a cluster
text	component of PCDHA@
STRUCTURE	190.57 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	repetitive sequence   other
text structure	the first large exon corresponding to the variable region A5 of the alpha cluster encodes the N terminal extacellular and transmembrane domains
	the three small last exons corresponding to the constant region of the alpha cluster encode the C terminal cytoplasmic domain (identical for each protein in the cluster)

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018908 4 - 5218 NP_061731 102 936 - Wu (2001) variable region A5 constant region of the alpha cluster NM_031501 1 - 2451 NP_113689 87 816 - Wu (2001) terminating downstream intron 1, putatively secreted

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	developing brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	six extracellular cadherin repeats
	a transmembrane segment encoded by a unique exon
	a cytoplasmic tail identical for each protein in the cluster
	two PXXP motifs and a putative SH3 protein-binding site

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Pcdha5 protocadherin alpha 5

intraspecies

homolog to cadherin

Homologene

FAMILY	cadherin superfamily
	protocadherin family

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction
text	integral membrane protein type 1, localized at the synaptic junction

basic FUNCTION

cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , nervous system

text	playing a putative role in cell-cell interaction critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process

PATHWAY

metabolism

signaling

neurotransmission

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cytoplasmic domain putatively connecting to intermediate filaments

cell & other

cells expressing the same protocadherin

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS