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FLASH GENE
Symbol INTU contributors: mct - updated : 25-08-2022
HGNC name inturned planar cell polarity effector homolog (Drosophila)
HGNC id 29239
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
cell lineage
cell lines chondrosarcoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • PDZ domain
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • protein binding activity
  • planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia
  • is required for ciliogenesis
  • cilia and planar polarity effector, that performs prominent ciliogenic functions during morphogenesis, such as in the skin
  • is essential for intraflagellar transport A complex assembly during ciliogenesis
  • INTU is indispensable during basal cell carcinoma (BCC) tumorigenesis and its aberrant upregulation is likely a prerequisite for primary cilia formation during Hh-dependent tumorigenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a subunit of the CPLANE multiprotein complex essential for the assembly of IFT-A particles and intraflagellar transport
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SRTD20 , OFD17
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human basal cell carcinoma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) signaling
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS