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FLASH GENE
Symbol MMP24 contributors: mct/npt - updated : 12-06-2010
HGNC name matrix metalloproteinase 24 (membrane-inserted)
HGNC id 7172
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils   highly
Nervousgangliasensory gangliadorsal root highly
 nervecranial nerve  highly
Reproductivefemale systemuterus  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningendometrium highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a prodomain (activation locus)
  • a zinc binding site in the catalytic domain
  • an hemopexin domain
  • a C terminal extension rich in hydrophobic residues characteristic of MT-MMPs, representing a putative transmembrane segment, the EWV motif
  • a cytoplasmic domain
  • conjugated HemoP , MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • matrix metalloproteinase (MMP) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text with a membrane type form
    basic FUNCTION
  • matrix metalloproteinase
  • pancreas and lung activator of MMP2
  • involved in neurogenesis
  • playing a role in the formation of endometriosis
  • essential mediator of peripheral thermal nociception and inflammatory hyperalgesia (Folgueras 2009)
  • plays an important role in cell-cell interactions between nociceptive neurites and mast cells (Folgueras 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding TIMPs in a 1:1 stoichiometry
  • N-cadherin is a substrate of MMP24 (Folgueras 2009)
  • cell & other
    REGULATION
    activated by furin( intracellularly) and proteinase
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in brain tumors
    constitutional     --over  
    in most peritoneal endometriosis lesions
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Mmp24-deficient mice display enhanced sensitivity to noxious thermal stimuli under basal conditions (Folgueras 2009)