Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MMP24

contributors: mct/npt - updated : 12-06-2010

HGNC name	matrix metalloproteinase 24 (membrane-inserted)
HGNC id	7172

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	50.27 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

motif	Viral sequence   long terminal repeat
text structure	specific HERV-K LTR within intron 4

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006690 9 - 4344 NP_006681 - 645 - Goetje (2007) variant 2 - - 1779 isoform 2 - 593 in the neurons and in the hippocampus Ross (2007) also called MT5-MMP var characterized by a 162 bp deletion within the signal and propeptide domains

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Nervous ganglia sensory ganglia dorsal root   highly   nerve cranial nerve     highly Reproductive female system uterus     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining endometrium   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide
	a prodomain (activation locus)
	a zinc binding site in the catalytic domain
	an hemopexin domain
	a C terminal extension rich in hydrophobic residues characteristic of MT-MMPs, representing a putative transmembrane segment, the EWV motif
	a cytoplasmic domain

conjugated

HemoP , MetalloP

HOMOLOGY

Homologene

FAMILY

matrix metalloproteinase (MMP) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	with a membrane type form

basic FUNCTION	matrix metalloproteinase
	pancreas and lung activator of MMP2
	involved in neurogenesis
	playing a role in the formation of endometriosis
	essential mediator of peripheral thermal nociception and inflammatory hyperalgesia (Folgueras 2009)
	plays an important role in cell-cell interactions between nociceptive neurites and mast cells (Folgueras 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein	binding TIMPs in a 1:1 stoichiometry
	N-cadherin is a substrate of MMP24 (Folgueras 2009)

cell & other

REGULATION

activated by

furin( intracellularly) and proteinase

inhibited by

TIMPs and TFPI2

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in brain tumors constitutional     --over   in most peritoneal endometriosis lesions

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Mmp24-deficient mice display enhanced sensitivity to noxious thermal stimuli under basal conditions (Folgueras 2009)