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FLASH GENE
Symbol PDCL contributors: mct - updated : 10-12-2014
HGNC name phosducin-like
HGNC id 8770
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a phosducindomain
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to murine Rpr1
homolog to rattus Pdcl
homolog to Drosophila CG7650
homolog to C.elegans f16h11.2
intraspecies homolog to PDC
Homologene
FAMILY phosducin gene family, subgroup I
CATEGORY chaperone/stress , receptor membrane G
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzing the formmaion of Gbetagamma dimer from its nascent polypeptides
  • works as a co-chaperone with the cytosolic chaperonin complex (TCP1) to fold Gbeta and mediate its interaction with Ggamma
  • is essential for G-protein assembly and signaling in retinal rod photoreceptors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • PDCL forms with Gbeta subunit and the cytosolic chaperonin complex CCT1 an intermediate complex required for association of Galpha
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • regulated py phosphorylation, by CSK2 and M-terminal splicing
  • phosducin and PDCL both bind G protein beta subunits with high affinity
  • thought to act as a TCP1 co-factor
  • protein
  • seems to stabilize the interaction of GNB5 with TCP1 until GNB5 is folded, after which it is released to allow GNB5 to interact with RGS7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS