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FLASH GENE
Symbol PDCL contributors: mct - updated : 10-12-2014
HGNC name phosducin-like
HGNC id 8770
Location 9q33.2      Physical location : 125.580.375 - 125.590.935
Synonym symbol(s) PHLP, DKFZp564M1863
DNA
TYPE functioning gene
STRUCTURE 10.55 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (TATA box)
MAPPING cloned Y linked Y status provisional
Map cen - D9S1876 - PDCL - D9S1674 - qter
Authors Thibault (99)
regionally located linked to markers D9S1876 and D9S1674
RNA
TRANSCRIPTS type messenger
text a long and a short isoforms involved in the regulation of expression
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 polyA site 1200 - 218 widely expressed 2013 23888055
  • short isoform
  • long isoform PhLP(L) and the short isoform PhLP(S) differ by the presence or absence of an 83-amino acid N terminus
  • long and short splice isoforms of phosducin-like protein stimulate and inhibit production of G proteins in the cell
  • can act as a negative regulator of the synthesis and assembly of heterotrimeric G proteins
  • strong inhibitory action of PhLP(S) on Gbetagamma signaling is the result of a previously unrecognized mechanism of Gbetagamma-regulation, inhibition of Gbetagamma-folding by interference with TCP1
    • 4 - 3085 - 301 - 2013 23888055
  • PDCL-LT
  • including multiple ARE elements in the 3'utr
  • long and short splice isoforms of phosducin-like protein stimulate and inhibit production of G proteins in the cell
  • directly inhibits Gbetagamma-stimulated signaling
    		•
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a phosducindomain
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Rpr1
    homolog to rattus Pdcl
    homolog to Drosophila CG7650
    homolog to C.elegans f16h11.2
    intraspecies homolog to PDC
    Homologene
    FAMILY phosducin gene family, subgroup I
    CATEGORY chaperone/stress , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the formmaion of Gbetagamma dimer from its nascent polypeptides
  • works as a co-chaperone with the cytosolic chaperonin complex (TCP1) to fold Gbeta and mediate its interaction with Ggamma
  • is essential for G-protein assembly and signaling in retinal rod photoreceptors
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • PDCL forms with Gbeta subunit and the cytosolic chaperonin complex CCT1 an intermediate complex required for association of Galpha
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • regulated py phosphorylation, by CSK2 and M-terminal splicing
  • phosducin and PDCL both bind G protein beta subunits with high affinity
  • thought to act as a TCP1 co-factor
    • protein
  • seems to stabilize the interaction of GNB5 with TCP1 until GNB5 is folded, after which it is released to allow GNB5 to interact with RGS7
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS