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FLASH GENE
Symbol SEC63 contributors: mct - updated : 10-06-2011
HGNC name SEC63 homolog (S. cerevisiae)
HGNC id 21082
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Endocrinepancreas   highly
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemuterus    Homo sapiens
Respiratoryrespiratory tractlarynx  predominantly
 respiratory tracttrachea  highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  moderately
Connectiveadipose  highly
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte Homo sapiens
Reproductiveepithelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text in fetal liver (
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DnaJ domain
  • Sec63 domain
  • a conserved BRL (Brr2-like) domain in the C-terminal cytosolic region that is essential for function
  • HOMOLOGY
    interspecies homolog to rattus Sec63 (96.1 pc)
    homolog to murine Sec63 (96.1 pc)
    Homologene
    FAMILY
    CATEGORY chaperone/stress , receptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    text
  • integral membrane protein located in the rough ER
  • basic FUNCTION
  • performing post-translational protein translocation into the ER (Sec61-Sec62-Sec63 complex)
  • performing the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway (Sec61-Sec62-Sec63 complex)
  • acting as an endoplasmic reticulum receptor
  • key component of the protein translocation machinery in the mammalian endoplasmic reticulum (ER), and involved in the post-translation processing of secretory proteins
  • possible role for SEC63 in decidualization
  • PRKCSH and SEC63 function in protein translocation and quality control pathways in the endoplasmic reticulum
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein-membrane targeting
    PATHWAY
    metabolism
    signaling
    a component
  • component of the transmembrane complex mediating posttranslational translocation of nescent peptides across the ER
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding with SEC62 to ribosome-free SEC61 complex
  • binding to heat shock protein
  • binding to unfolded protein
  • NXN is an interaction partner of SEC63
  • is linked to the Wnt signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to PCLD
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCLD2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS